Nature

A mechanistic overview of translation initiation in eukaryotes

In eukaryotes, translation initiation is the most highly regulated phase of the translation cycle 1. Its goal is to assemble the large (60S) and small (40S) ribosomal subunits into an ...
Nature

AN INITIATION CODON MUTATION IN THE α1 GLOBIN GENE OF A BLACK FAMILY WITH HbH DISEASE

In α thalassemia, molecular analysis has revealed deletion and non-deletion defects, of which deletion mutations are the most common. To date the non-deletion defects described have involved the α2 ...
JSTOR Daily

Initiation of Protein Synthesis from a Termination Codon

This is a preview. Log in through your library . PNAS is the world's most-cited multidisciplinary scientific serial. It publishes high-impact research reports, commentaries, perspectives, reviews, ...
Fred Hutch

Influenza exploits an alternate route when it comes to protein synthesis

Genes must be expressed in precise levels and at the exact moment if the complex balance regulating cell activity is to be maintained. Messenger RNA (mRNA) conveys genetic information from DNA to ...
JSTOR Daily

Initiation Factor IF-3-Dependent Binding of Escherichia coli Ribosomes and N-Formylmethionine Transfer-RNA to Rabbit Globin Messenger

An initiation complex has been formed in high yields from E. coli ribosomes, 9S messenger RNA for rabbit hemoglobin, and N-formylmethionine-tRNA. Initiation factor IF-3 is required for the binding and ...