Using a novel automated microfilling system, the authors demonstrate that roller compaction followed by milling is a viable preprocessing technique for high-dose chemical-in-capsule dosage forms. The ...

Although tablet manufacture is traditionally a batchbased wet granulation process, there are many advantages to be gained by adopting dry granulation, including lower costs and increased yields.

Dry granulation, also called roller compaction, has been a popular method in recent years and has many applications. The powder is compressed between revolving rollers to generate flakes. The flakes ...